Welcome to the Kaplan Lab at UC Davis

Budding yeast after replication stress. The circle indicates the position of the nucleus. Nvj1 (red) shows the targeting of part of the nucleus to the vacuole and the relative position of Fob1, a nucleolar marker. (Image credit: Jonathan Do and Ken Kaplan)


Research Interests:

My lab focuses on cellular pathways that preserve genome integrity during mitosis. We are especially focused on anaphase and how the major events of anaphase are coordinated with DNA replication to ensure proper sister chromatid resolution. In studying these pathways, we have grown more generally interested in how normal cells transition into disease states, states that support aneuploidy in cancer or that result in progressive failures in cell functions in neurodegenerative disease.